A girl born today in the UK can expect to live nearly to the age of 82 on average, while her brother will live to 78. They would have a longer life in Andorra (85 and 79 respectively) but are marginally better off than in the US (81 and 76), while if they lived in the Central African Republic, they would barely make it out of middle age (49 and 44). Nonetheless, almost everywhere in the world, with the exception of countries such as Lesotho, which have been hit by HIV and violence, lifespans are lengthening and the best news is that small children are substantially less likely to die than they were four decades ago. There has been a drop in deaths among under-fives of nearly 60%, from 16.4 million in 1970 to 6.8 million in 2010. That in itself is justification for the enormous project that the Institute of Health Metrics and Evaluation (IHME) in Seattle has led over the past five years, involving nearly 500 researchers, to assess the global burden of disease. Knowing how many children die and from what cause enables the world to focus its efforts and resources on keeping them alive. There are many lessons to be gleaned from the vast database they have put together, which will help global organizations and individual governments to better care for us all – from a renewed focus on diet to tackling alcohol to keeping up the efforts against HIV in Africa. The seven papers